Indiana University Center for Medical Genomics Array1

… to provide infrastructure for the
use of genomic technologies ...
• Microarrays
• High throughput genotyping

    The Center for Medical Genomics provides consultation, infrastructure and expertise in use of microarrays to investigators at the Indiana University School of Medicine and other Universities in Indiana. This includes consultation in the design of these experiments and in minimizing experimental variability; for this reason, it is useful to consult with the Center at the earliest phase of planning experiments. The Center also provides data analysis and bioinformatics expertise needed to interpret the large amount of data generated in these experiments. Much effort has gone into experimental consistency and quality control at all steps.

    Use of large-scale microarrays to explore the expression of tens of thousands of genes at once can identify global patterns of gene regulation. Typical questions include
    • Why are some tumors aggressive and others relatively easy to treat?
    • Why do some people with a given disease respond to treatment and others don’t?
    • How does a drug work?
    • Are there new targets for drug development?

It is important to consult with the Center for Medical Genomics before setting up the experiment.

Microarray Services:

• Affymetrix GeneChips® When they are available for the organism in question, we strongly recommend these GeneChips.

• Custom-made spotted arrays We can consult about constructing arrays for model organisms for which GeneChips are not currently available, or small arrays for followup experiments.

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The Center for Medical Genomics is partially supported by a competitive, peer-reviewed grant from the State of Indiana 21st Century Research and Technology Fund. Additional support is from the Indiana Genomics Initiative, funded by a generous grant from the Lilly Endowment, and from the Indiana University School of Medicine.